How Come After Re-Dosing, Amphetamines Lose the Euphoric Effect?

Question by Ryan: How come after re-dosing, amphetamines lose the euphoric effect?
So lets say some one takes some adderal and feel really good, after a few hours the euphoria fades so you take more. But the second dose really does not stimulate the mind, causing euphoria, only the body.

Best answer:

Answer by Censure 455
The euphoria comes from the release of dopamine in the brain which binds to dopaminergic receptors causing the feeling of euphoria. However as more dopamine is released into the brain the dopaminergic receptors begin to be either binded already or gain resistance to the dopamine and the resulting pathway is not activated. This means that even if you take larger doses of dopamine (adderall) you won’t feel its effects as greatly because the brain requires time to decrease the tolerance levels of the receptors for the effects to be felt.

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